https://www.maw-consult.com/contact daily 0.75 2026-03-12 https://www.maw-consult.com/aboutme daily 0.75 2026-04-04 https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/956f761b-66c3-4d76-8034-ff54060b40f9/Matthew+Wyczalkowski-IMG_4157.jpg https://www.maw-consult.com/home daily 1.0 2026-03-23 https://www.maw-consult.com/gallery daily 0.75 2026-03-02 https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/2ac9ce81-b6ad-4d15-9e7c-ed8febac440d/PortfolioDay_1.png Gallery - old - A visual summary of principal genomics findings across 33 cancer types The Cancer Genome Atlas (TCGA) project spanned 15 years and collected 10,000+ cancer samples across 33 cancer types. This figure is a visual summary of its principal findings for a recent review article. Displaying large quantities of data to make it accessible and digestable can be challenging. My approach here is based on baseball cards: to visualize a multiple information sets by placing them in regular positions, encouraging visual exploration and comparison. Twelve different datasets are displayed for each cancer type, with quantitative information elements generated in R and final assembly and layout in Adobe Illustrator. The resulting figure successfully makes clear observations such as the prevelance of TP53 mutations, and the relative increase in mutation frequency in skin and lung cancers. Published in Chen, F., Wendl, M.C., Wyczalkowski, M.A. et al. Moving pan-cancer studies from basic research toward the clinic. Nat Cancer 2, 879–890 (2021). https://doi.org/10.1038/s43018-021-00250-4 PDF of figure https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/17d8fd80-2e81-4a6a-821d-8803c52c9ecc/PortfolioDay_2.png Gallery - old - Multi-year tissue sample collection strategy for a grant proposal Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/e5ed1f34-a1b7-4a29-ab63-2bd2fbc22487/WebSiteContent.v3.p_24.png Gallery - old - Immunological engineering strategies for cancer therapy Immune cell control strategies for cancer therapy illustrated for the book Gene and Cellular Immunotherapy for Cancer. I provide a visual representation for a number of immunological engineering techniques to an audience of clinicians and researchers in the field. To communicate effectively with this audience, it was important to become familiar with the technical content as well as existing visual conventions - having a background in biomedical research is very helpful in doing so. The final figure illustrates the technical points in an accessible and visually appealing way, and complements other figures throughout the book. Gene and Cellular Immunotherapy for Cancer (Springer, 2022) https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/325bf339-1682-4af2-bedc-daed5cfbfed8/PollockB.v2.1.png Gallery - old - Details of a machine learning algorithm and training strategy Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/dcb17466-e6e9-4d6e-93fb-2271cb27f1c1/TCGA-BA-4077-01B-01D-2268-08.AA.chr14.BreakpointSurvey.png Gallery - old - BreakpointSurveyor is an automated pipeline for visualizing genomic data BreakpointSurveyor is a bioinformatics and data visualization pipeline I developed to visualize complex viral integration events in genomic data. Its innovative 2D visualization technique allows a number of lines of evidence of virus integration into the human chromosome in cancer to be portrayed clearly, and was used to screen large numbers of such events. This comprehensive computational pipeline includes bioinformatics preprocessing as well as visualization steps, was published and is available on GitHub. M.A. Wyczalkowski, et al.; BreakPoint Surveyor: A Pipeline for Structural Variant Visualization. Bioinformatics 2017. doi: 10.1093/bioinformatics/btx362 https://www.maw-consult.com/portfolio daily 0.75 2026-04-04 https://www.maw-consult.com/portfolio/project-one-f5w4d-z9nem-s3jda-eyssk-a6prr-z484y monthly 0.5 2026-03-11 https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/9cb52dad-dc9a-4c94-8083-43e5956b6c4f/Portfolio+2026__Abstract2.png Portfolio - Graphical Abstracts A graphical summary of a manuscript published in Cell, illustrating the multi-scale analysis of ten cancer types to provide insights into mechanisms driving cancer. Published in Li et al., Cell (2003). Click image for details https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/7b0eac72-f5c4-4758-9a89-4813430bbf69/Portfolio+2026__Abstract6.png Portfolio - Graphical Abstracts Visual representation of data collection across spatial scales for the HTAN project. A version of this illustration was published as part of a Nature special feature on the Human Tumor Atlas Network. Click image for details. https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/570aea44-c805-4369-976f-d2589b161e29/Portfolio+2026__Abstract3.png Portfolio - Graphical Abstracts This illustration is the first figure in a grant application for the Human Tumor Atlas Network, providing a visual summary of the aims of the proposal. This successful grant application resulted in a $9.6M award to Washington University (2018-2024). Click image for details https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/9249fc4c-72f1-4c31-8f02-2c3fe2aa9773/Portfolio+2026__Abstract8.png Portfolio - Graphical Abstracts https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/8d66ddad-d2e7-44c3-930b-08ba48924e83/Portfolio+2026__Abstract11.png Portfolio - Graphical Abstracts https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/f56e99f4-54bb-4ddf-85d8-7e6c85fe82d6/Portfolio+2026__Abstract12.png Portfolio - Graphical Abstracts Overview of pan-cancer studies. Published in Nature Cancer (2021). Click link for details https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/a5200f14-3f1b-4c3c-ab2f-f2a4854a3b63/Portfolio+2026b_Abstract13.png Portfolio - Graphical Abstracts https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/51105690-abc8-488c-b6a4-92b1b75755ac/Portfolio+2026-new_new2.png Portfolio - Graphical Abstracts https://www.maw-consult.com/portfolio/project-one-f5w4d-z9nem-s3jda-eyssk-a6prr-z484y-f2lnr monthly 0.5 2026-03-11 https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/b6ecdd1c-ba12-4a62-a1a8-e13c4a2c2917/Portfolio+2026_Book25.png Portfolio - Infographics Next generation CAR-T cell modifications (2022): Visual description of a variety of CAR-T technologies associated with cancer immunotherapy. Published in Gene and Cellular Immunotherapy for Cancer. Click image for details https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/c4beeaad-3ac1-4e8c-8e29-623bfd5bad1a/Portfolio+2026_Book26.png Portfolio - Infographics https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/b19e007c-3d1e-458b-8c5f-d5686ada9964/Portfolio+2026_book28.png Portfolio - Infographics Published in Gene and Cellular Immunotherapy for Cancer https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/25b8804b-9014-4328-8d97-dca938e1b1f6/Portfolio+2026_book29.png Portfolio - Infographics Published in Gene and Cellular Immunotherapy for Cancer https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/2dd7757d-d843-4169-843f-2085687ea9a6/Portfolio+2026_book30.png Portfolio - Infographics Published in Gene and Cellular Immunotherapy for Cancer https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/4fc4a5b3-85d3-4074-8716-bc9423453538/Portfolio+2026_book32.png Portfolio - Infographics https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/7b7c2e6f-81bf-40c6-9437-c6e2dbbd4bea/Portfolio+2026b_book34.png Portfolio - Infographics https://www.maw-consult.com/portfolio/project-one-f5w4d-z9nem-s3jda-eyssk-a6prr-z484y-f2lnr-66r6m monthly 0.5 2026-03-11 https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/e74e2ad4-df93-4fab-9b7a-aaf36802915a/Portfolio+2026_Data34.png Portfolio - Data Visualization Key characteristics of cancers learned from TCGA (Nature Cancer, 2021): Published as part of a retrospective on the landmark TCGA cancer genomics program, this is a visual representation of the key findings of genomics analyses across 33 cancer types. Each panel provides a concise summary of findings for each cancer, including incidence, and survival rates, mutational signatures and associated driver genes. Click image for details https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/249972cd-cbf2-4752-8ca8-1c040f40e704/Portfolio+2026_Data35.png Portfolio - Data Visualization Genetic mutations across cancer types (Nature, 2013): Key figure in a landmark paper illustrating patterns of genetic mutations across cancer types. Click image for details https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/185b16cf-7ae9-4004-95bf-93253d1a649b/Portfolio+2026_Data36.png Portfolio - Data Visualization Patterns of plasma cell subpopulation shift from Primary to Relapse (Nature Communications, 2021): A complex multi-panel data figure illustrating the changes in plasma cell populations in multiple myeloma relapse. Click image for details https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/f36b2e38-b958-423d-98e9-982e69d7f4b3/Portfolio+2026_Data44.png Portfolio - Data Visualization BreakpointSurveyor is a bioinformatics and data visualization pipeline developed to visualize complex viral integration events in genomic data. Its innovative 2D visualization technique allows a number of lines of evidence of virus integration into the human chromosome in cancer to be portrayed clearly, and was used to screen large numbers of such events. This comprehensive computational pipeline includes bioinformatics preprocessing as well as visualization steps, was published and is available on GitHub (click image). Published as: M.A. Wyczalkowski, et al, Bioinformatics (2017) DOI: 10.1093/bioinformatics/btx362 https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/2d3d3800-2637-4fa9-b421-8b1bed1794ec/Portfolio+2026_Data43.png Portfolio - Data Visualization Visualization of gene expression disregulation in the vicinity of viral integration. The bottom panel is generated by Breakpoint Surveyor. Click the image for code and additional details https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/98bb76c4-56fc-4e0b-8a77-c1b9817b880a/Portfolio+2026_Data45.png Portfolio - Data Visualization Summary of evidence of viral integration for a cohort of samples from next generation sequencing data, part of the Breakpoint Surveyor project https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/715125d6-f4f8-4816-b105-33e53afc3194/Portfolio+2026b_Data44.png Portfolio - Data Visualization https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/f1da3e65-8cf9-43c8-b612-11c58a9acb01/Portfolio+2026-new_new3.png Portfolio - Data Visualization Figure published in Terekhanova, N.V. et al. Epigenetic regulation during cancer transitions across 11 tumour types. Nature 623, 432–441 (2023). https://www.maw-consult.com/portfolio/project-one-f5w4d-z9nem-s3jda-eyssk-a6prr-z484y-f2lnr-66r6m-p97jg monthly 0.5 2026-03-11 https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/8d1c5ab0-cf65-4f78-9def-f8cecf961216/Portfolio+2026_Experime48.png Portfolio - Experiment Design Therapeutic targets and treatment responses across cancer types (2021): Illustration of a strategy for preclinical studies and clinical trials based on molecular features. Published in Nature Cancer (click image for details) https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/b5ed7238-c540-475c-9c3b-a10d0287de63/Portfolio+2026_Experime52.png Portfolio - Experiment Design https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/53b9372a-3cae-45ae-bf5f-c0dba36b4e1f/Portfolio+2026_Experime58.png Portfolio - Experiment Design https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/d47a759c-52b2-4451-841c-591fc623d1de/Portfolio+2026_Experime59.png Portfolio - Experiment Design https://www.maw-consult.com/portfolio/project-one-f5w4d-z9nem-s3jda-eyssk-a6prr-z484y-f2lnr-66r6m-p97jg-y8dcp monthly 0.5 2026-03-11 https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/775c4532-62a9-480a-8231-bb15319658a2/Portfolio+2026_workflow13.png Portfolio - Workflow Figures "Pollock" machine learning algorithm (2022): A visual representation of the algorithm underlying the "Pollock" software package, designed for the classification of single cell transcriptome data. Click image for details https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/1778467230943-EAVIDNH1ZT0LGCNIFTD2/Portfolio%2B2026_workflow18.png Portfolio - Workflow Figures https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/b371fd64-e4ff-4c9a-8aeb-891b4f82e94c/Portfolio+2026_workflow22.png Portfolio - Workflow Figures https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/081ef813-636b-4a4f-8439-c6becc73bbc6/Portfolio+2026b_Workflow24.png Portfolio - Workflow Figures https://images.squarespace-cdn.com/content/v1/60b667f3e3dd0471f488cf21/86e2a5f7-e257-4353-b0b2-d1fbaf848a0f/Portfolio+2026-new_new1.png Portfolio - Workflow Figures Figure published in Martins Rodrigues F, Terekhanova N, Imbach K et al., Precision proteogenomics reveals pan-cancer impact of germline variants. Cell, 2025; 188, 2312-2335.e26